Monoamines in glioblastoma: complex biology with therapeutic potential

Therapeutic Potential of Glioblastoma Stem Cells

Primary and the secondary GBM, these are the two distinct disease entity. The genetic and the epigenetic background of these tumors are highly variable and the treatment procedure of these tumors is not curable because of the cellular heterogeneity and intrinsic ability of the tumor cells to invading healthy tissues. The fatal outcomes of these tumors promote the researchers to find out new mar...

Uncovering therapeutic targets for glioblastoma: a systems biology approach.

Even though glioblastoma, WHO grade IV (GBM) is one of the most devastating adult cancers, current treatment regimens have not led to any improvements in patient life expectancy or quality of life. The constitutively active EGFRvIII receptor is one of the most commonly mutated proteins in GBM and has been linked to radiation and chemotherapeutic resistance. To define the mechanisms by which thi...

Glioblastoma Stem-Like Cells—Biology and Therapeutic Implications

The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) fro...

Mechanisms of Aggressiveness in Glioblastoma: Prognostic and Potential Therapeutic Insights

Brown adipose tissue biology and therapeutic potential

BROWN ADIPOSE TISSUE Brown adipose tissue (BAT) (Figure 1) has been recognized as a key thermogenic tissue in rodents for several decades. However, in the last few years, there has been a resurgent interest in the biology and therapeutic potential of BAT. This has been largely driven by a new understanding that most, if not all, healthy adult humans have significant deposits of BAT which can be...